Vergleich der Zilienschlagfrequenzen von gesunden Probanden bei verschiedenen Untersuchungstemperaturen und Etablierung von Normwerten
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Philipps-Universität Marburg
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Abstract
Primary ciliary dyskinesia is a rare genetic disorder, which originates in ciliary defects that affects mucociliary clearance of the lung and causes recurrent infections of the res- piratory tract alongside with other symptoms. Considering that a striking number of cases is not diagnosed, it can be assumed that the prevalence of about 1:20.000 is un- derestimated. High-Speed video analysis is the firstline method in case of suspected primary ciliary dyskinesia but provides different results depending on the method used to measure ciliary beat frequency. Therefore, the guidelines of the European Respiratory Society for diagnosis of primary ciliary dyskinesia (2017) recommended for each center to define their own normative data until a consensus is reached to allow standardisation of the methods.
According to the guidelines, it was the aim of this study to establish normative data for ciliary beat frequency, to analyse temperature-dependency of ciliary beat frequency and to measure the temperature in the nasal cavity with a noninvasive method.
Nasal brushings taken from 100 healthy adults, age range 20,2 – 31,9 years, were ana- lyzed. The median ciliary beat frequency was 7,0 Hz at 25 °C, 7,6 Hz at 32 °C and 8,0 Hz at 37 °C. The differences were statistically significant among the three tempera- tures (p<0,0001). The calculation of normative values revealed the following ranges of the ciliary beat frequency: 25 °C: 6,3 - 8,8 Hz; 32 °C: 6,3 – 9,0 Hz und 37 °C: 6,7 -
9,8 Hz. Except for a few studies that showed higher results but used different methods, our own data were well in accordance with those that used the same method for measur- ing ciliary beat frequency. In addition, we measured a median temperature of 30,2 °C at the nasal mucosa, which matches the results of other studies and allows the recommen- dation of 32 °C as optimal temperature to measure ciliary beat frequency.
In conclusion this study helps to determine normative data of ciliary beat frequency not only in our own institution but can also contribute to establish a consensus among the different centers for the future.
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Dates
Created: 2021Issued: 2021-11-02Updated: 2021-11-02
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
DFG-subjects
Primäre Ciliäre DyskinesiePCD,ZilienschlagfrequenzZilienCBF
DDC-Numbers
610
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Hahn, Jana: Vergleich der Zilienschlagfrequenzen von gesunden Probanden bei verschiedenen Untersuchungstemperaturen und Etablierung von Normwerten. : Philipps-Universität Marburg 2021-11-02. DOI: https://doi.org/10.17192/z2021.0367.
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This item has been published with the following license: In Copyright