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Philipps-Universität Marburg
Supervisors
Abstract
Carcinoma of the prostate is the most common
malignancy diagnosed in German men. Since the prostate spezific
antigen (PSA) is routinely used as a tumor marker a stage-shift
from advanced tumors to localized tumors has been noted. The
aim of this study was to evaluate demographic, clinical,
histopathology and quality of life data of 686 patients who
underwent a radical retropubic prostatectomy between 1989 and
1999 at the department of urology in Marburg. The initial
hypothesis that patients from rural areas present with a higher
stage prostate cancer compared to city dwellers could be
disproved. In both patient groups the number of advanced tumors
reduced in the same extense in a period of 5 years. We could
show that the screening programs and the urologic health care
in both areas are comparable. Patients younger than 55 years
were likely to have a higher probability of recurrence than
patients older than 65 years. The following parameters
including PSA, T-stage and grading were not significantly
different in both groups. We conclude from these data that
patients with prostate cancer at an avarage age of younger than
55 years do not suffering from a more aggressiv tumor. Although
a positiv nodal status had a significant impact on PSA, T-stage
and grading, the incidence of recurrence and the long term
survival did not differ in this group compared to the group
with negativ lymph node status. An other issue of this study
was to evaluate whether the radical prostatectomy is justified
in patients with a PSA higher than 20 ng/ml. Analysis of the
data revealed that PSA value of more than 20 ng/ml correlates
with a higher incidence of advanced carcinomas, positiv
lymphnodes and recurrences, but the long term survival of these
patients was 82%. Therefore we concluded that radical
prostatecotmy should not be denied to these patients. The
majority of the patients reported good to excellent qualitiy of
life with respect to incontinence and impotence using a
validated and home made questionnaire. 93.5% of the patients
would undergo surgery again. In conclusion this analysis of 686
patients verified that the radical prostatectomy is a valid
approach for prostate cancer with excellent tumor controll and
quality of life.
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Dates
Created: 2004Issued: 2004-04-01Updated: 2011-08-10
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
PSAprostate cancerquality of life,
DFG-subjects
ProstataProstata-spezifisches AntigenProstatakrebsLebensqualität
DDC-Numbers
610
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Wille, Julia (128939478): Klinische Charakteristika des lokal begrenzten Prostatakarzinoms. : Philipps-Universität Marburg 2004-04-01. DOI: https://doi.org/10.17192/z2004.0211.
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This item has been published with the following license: In Copyright