Die Wirkung intrathekaler Baclofenapplikation auf die Freisetzung von Adrenalin, Noradrenalin und Homovanillinsäure aus dem Nucleus paraventricularis hypothalami der Ratte
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Philipps-Universität Marburg
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Abstract
Abstract
Introduction:
In the clinical
observation of patients suffering from spastic and autonomous
dysregulation with hypertonia, intrathecal application of
baclofen improved both symptoms.
Aim:
In this study we
investigated the correlation of intrathecal application of
baclofen, a specific GABAB ? receptor agonist, and the
release of epinephrine, norepinephrine and homovanillin acid
from the hypothalamic paraventricular nucleus. The study was
part of a collaborative project in which dihydroxyphenylacetic
acid (DOPAC), 5 ? hydroxytryptamine (5 ? HT),
glutamate and aspartate were quantified while blood pressure
was measured. Homovanillic acid (HVA) as a decomposition
product of norepinephrine, epinephrine and dopamine was used as
a parameter for the release of dopamine. The magnocellular part
of the nucleus paraventricularis hypothalami has
neuroendocrinological functions and its parvocellular part
plays a role in the central control of autonomous functions,
e.g. control of blood pressure.
Method:
We implanted a
microdialysis probe in the nucleus paraventricularis
hypothalami of 38 Wistar-Rats. In 19 animals 1.5 mg Baclofen
was injected in the lateral ventricel and the equivalent
quantity of ringer?s solution in the remaining 19 animals
as a control group. Norepinephrine, epinephrine and the
metabolite HVA were quantified by HPLC.
Result:
There was no
significant difference between the baclofen and control group
concerning the release of epinephrine and norepinephrine from
the nucleus paraventricularis hypothalami. A significant
increase of HVA concentration was observed in the animals
treated with baclofen compared to the control group.
Outlook:
To prove the role of the paraventricularis hypothalamic
nucleus in the control of blood pressure and the influence of
baclofen on the release of epinephrine, norepinephrine and HVA
further studies have to follow.Abstract
Introduction:
In the clinical
observation of patients suffering from spastic and autonomous
dysregulation with hypertonia, intrathecal application of
baclofen improved both symptoms.
Aim:
In this study we
investigated the correlation of intrathecal application of
baclofen, a specific GABAB ? receptor agonist, and the
release of epinephrine, norepinephrine and homovanillin acid
from the hypothalamic paraventricular nucleus. The study was
part of a collaborative project in which dihydroxyphenylacetic
acid (DOPAC), 5 ? hydroxytryptamine (5 ? HT),
glutamate and aspartate were quantified while blood pressure
was measured. Homovanillic acid (HVA) as a decomposition
product of norepinephrine, epinephrine and dopamine was used as
a parameter for the release of dopamine. The magnocellular part
of the nucleus paraventricularis hypothalami has
neuroendocrinological functions and its parvocellular part
plays a role in the central control of autonomous functions,
e.g. control of blood pressure.
Method:
We implanted a
microdialysis probe in the nucleus paraventricularis
hypothalami of 38 Wistar-Rats. In 19 animals 1.5 mg Baclofen
was injected in the lateral ventricel and the equivalent
quantity of ringer?s solution in the remaining 19 animals
as a control group. Norepinephrine, epinephrine and the
metabolite HVA were quantified by HPLC.
Result:
There was no
significant difference between the baclofen and control group
concerning the release of epinephrine and norepinephrine from
the nucleus paraventricularis hypothalami. A significant
increase of HVA concentration was observed in the animals
treated with baclofen compared to the control group.
Outlook:
To prove the role of the paraventricularis hypothalamic
nucleus in the control of blood pressure and the influence of
baclofen on the release of epinephrine, norepinephrine and HVA
further studies have to follow.
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Dates
Created: 2003Issued: 2003-12-22Updated: 2011-08-10
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
hypothalamic paraventricular nucleusnorepinephrine , homovanillic acidbaclofenepinephrine
DFG-subjects
Nucleus paraventricularisBaclofenAdrenalin , NoradrenalinHomovanillinsäure
DDC-Numbers
610
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Czell, David (128603275): Die Wirkung intrathekaler Baclofenapplikation auf die Freisetzung von Adrenalin, Noradrenalin und Homovanillinsäure aus dem Nucleus paraventricularis hypothalami der Ratte. : Philipps-Universität Marburg 2003-12-22. DOI: https://doi.org/10.17192/z2003.0720.
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