Item type:Thesis, Open Access

Die Regulation des nucleären Kalziumtransienten in ventrikulären Kardiomyozyten

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Date

2019-05-23

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Philipps-Universität Marburg
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Abstract

In conclusion, this study reveals the cytoplasmic CaT as the most important determinant of the nuclear Ca increase and provides evidence that SERCA function directly modulates passive Ca propagation into the nucleus. Moreover, under physiological conditions, perinuclear Ca load only plays a minor role in the regulation of nuclear Ca. Finally, the major results from WKY rats could be reproduced in SHR, which confirmed the findings and provides an indication of their transferability and validity.

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Dates
Created: 2019Issued: 2019-05-23Updated: 2019-05-23
DOI
https://doi.org/10.17192/z2019.0216
Faculty
Fachbereich Pharmazie
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
calcium regulationnuclear calciumhypertrophySERCAcardiomyocytes
DFG-subjects
KernkalziumKardiomyozytenKalziumregulationHypertrophieSERCA
DDC-Numbers
615
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2019.0216
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Kiess, Tobias-Oliver: Die Regulation des nucleären Kalziumtransienten in ventrikulären Kardiomyozyten. : Philipps-Universität Marburg 2019-05-23. DOI: https://doi.org/10.17192/z2019.0216.

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 - CC BY NC ND
Except where otherwised noted, this item's license is described as Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 - CC BY NC ND