Item type:Thesis, Open Access

Charakterisierung von Osteoprotegerin (OPG) und Receptor Activator of NF-kB-Ligand (RANKL) in der Schilddrüse

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Date

2005-12-27

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Philipps-Universität Marburg
DOI

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Abstract

Receptor activator of NF-kB-Ligand (RANKL) and osteoprotegerin (OPG) play essential roles in bone metabolism and immun responses. RANKL activates RANK, wich is expressed by osteoclasts and dendritic cells, whereas OPG acts as its decoy receptor. The role of RANKL and OPG in thyroid physiologie remainded unclear. The shown data suggest that RANKL and OPG are produced in the thyroid galnd by thyroid follicular cells, are regulated by cytokines and TSHm, and are capable of modulating dendritic cell functions. Thus, these cytokines may represent important local immunmregulatory factors involved in the pathogenesis of autoimmun thyroid diseases.

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Dates
Created: 2005Issued: 2005-12-27Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2005.0708
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Dendritic cellsDendritische ZellenRANKLAutoimmun diseasesOPGOPGThyroidRANKL
DFG-subjects
Basedow-KrankheitSchilddrüseAutoaggressionskrankheit
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2005.0708
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Kluger, Sibylle: Charakterisierung von Osteoprotegerin (OPG) und Receptor Activator of NF-kB-Ligand (RANKL) in der Schilddrüse. : Philipps-Universität Marburg 2005-12-27. DOI: https://doi.org/10.17192/z2005.0708.

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