Charakterisierung von Osteoprotegerin (OPG) und Receptor Activator of NF-kB-Ligand (RANKL) in der Schilddrüse
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Philipps-Universität Marburg
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Receptor activator of NF-kB-Ligand (RANKL) and osteoprotegerin (OPG) play essential roles in bone metabolism and immun responses. RANKL activates RANK, wich is expressed by osteoclasts and dendritic cells, whereas OPG acts as its decoy receptor. The role of RANKL and OPG in thyroid physiologie remainded unclear. The shown data suggest that RANKL and OPG are produced in the thyroid galnd by thyroid follicular cells, are regulated by cytokines and TSHm, and are capable of modulating dendritic cell functions. Thus, these cytokines may represent important local immunmregulatory factors involved in the pathogenesis of autoimmun thyroid diseases.
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This item has been published with the following license: In Copyright