Item type:Doctoral Thesis, Open Access

Klonale experimentelle autoimmune Enzephalomyelitis: T-Zell-Charakteristika bestimmen die Läsionspathologie

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Date

2006-10-05

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Philipps-Universität Marburg
DOI

Supervisors

Abstract

Experimental autoimmune encephalomyelitis (EAE)is a well known animal model of Multiple sclerosis. In this study EAE was induced by the adoptive transfer of PLP139-51 specific T cell clones into SJL/J mice. Encephalitogenic Th1 T cell clones induced the typical mononuclear EAE lesions in the spinal cord and optic nerve, whereas EAE lesions induced by a Th2 type T cell clone were characterized by eosinophilic infiltrates, with abundant Ig deposition and considerable tissue destruction. Antibody responses in T cell clone transfered animals revealed early epitope spreading to other myelin antigens.

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Dates
Created: 2006Issued: 2006-10-05Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2006.0638
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
EAET-Zell KloneLäsionspathologieLesion pathologyT cell clonesEpitope spreadingEpitope spreading
DFG-subjects
LymphozytEncephalomyelitis
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2006.0638
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Nessler, Stefan (132091488): Klonale experimentelle autoimmune Enzephalomyelitis: T-Zell-Charakteristika bestimmen die Läsionspathologie. : Philipps-Universität Marburg 2006-10-05. DOI: https://doi.org/10.17192/z2006.0638.

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