Item type:Thesis, Open Access

Systematische Analyse von Rezeptoren und Effektormechanismen der pulmonalen angeborenen Immunität

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Date

2009-10-09

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Philipps-Universität Marburg
DOI

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Abstract

The airway epithelium is an important interface with the environment, and represents a dynamic system for innate host defense. In addition to providing a barrier to the entry of pathogens, epithelial cells lining the airway have been shown to respond to the presence of microorganisms by producing natural antimicrobial factors and mounting an inflammatory response. Toll-like receptors (TLR) play an important role in pathogen recognition and innate immunity. To date ten family members of the TLR family are known in the human genome. In this study the expression and function of the TLR 1-10 in different epithelial cell-lines of the lung and primary cells were explored and compared with each other. In addition we explored the expression and function of TLR 1-10 in endothelial primary cells. In this study the expression of the antimicrobial peptide psoriasin (S100A7) in the lung could be shown.

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Dates
Created: 2009Issued: 2009-10-09Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2009.0604
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Toll-like receptorsInnate immunityLung
DFG-subjects
Angeborene ImmunitätLungeToll-like-Rezeptoren
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2009.0604
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Stanze, Daniel (139405526): Systematische Analyse von Rezeptoren und Effektormechanismen der pulmonalen angeborenen Immunität. : Philipps-Universität Marburg 2009-10-09. DOI: https://doi.org/10.17192/z2009.0604.

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This item has been published with the following license: In Copyright