Item type:Thesis, Open Access

Polymere Implantatmaterialien für die kontrollierte lichtinduzierte Freisetzung von Wirkstoffen

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Date

2010-09-22

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Philipps-Universität Marburg
DOI

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Abstract

The development and characterization of polymeric implant materials for the photo-induced release of the cytostatic drug 5-fluorouracil is described in this work. The materials (respectively the implants made from these materials) are designed to work as replacement for the natural lens of the human eye during cataract surgery. The incorporated drug depot provides an alternative method for the treatment of secondary cataract, a common post-operative complication. Two different types of polymers were investigated, both suitable for the fabrication of modern foldable intraocular lenses: hydrophobic and hydrophilic polyacrylates. The drug immobilization is based on the photochemical reversible [2+2]-cycloaddition of 5-fluorouracil respectively a 5-fluorouracil pro-drug to polymer bound coumarin groups. The cycloreversion which can be triggered by a single- or two-photon-absorption process is therefore equivalent to the drug release mechanism.

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Dates
Created: 2010Issued: 2010-09-22Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2010.0480
Faculty
Fachbereich Chemie
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
5-FluoruracilPolymere IntraokularlinseControlled drug releaseCoumarinPhotochemisch ansprechbarPhoto-inducedPolymeric intraocular lens5-fluorouracil
DFG-subjects
CumarinderivateKontrollierte Wirkstofffreisetzung
DDC-Numbers
540
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2010.0480
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Sinkel, Carsten (133568172): Polymere Implantatmaterialien für die kontrollierte lichtinduzierte Freisetzung von Wirkstoffen. : Philipps-Universität Marburg 2010-09-22. DOI: https://doi.org/10.17192/z2010.0480.

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This item has been published with the following license: In Copyright