Prognostische Bedeutung morphometrischer endomyokardialer Biopsieanalysen bei Patienten mit dilatativer Kardiomyopathie
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Philipps-Universität Marburg
Abstract
BACKGROUND: To date, considerable controversy
exists on the prognostic significance of morphometric
endomyocardial biopsy findings in patients with idiopathic
dilated cardiomyopathy (IDC). METHODS: Quantitative analyses of
interstitial structured tissue, myofibril volume fraction, and
myocytic fiber diameters of left ventricular endomyocardial
biopsy specimens were performed in 124 patients with IDC.
RESULTS: During 51 +/- 22 months follow-up after left
ventricular endomyocardial biopsy, major arrhythmic events,
defined as sustained ventricular tachycardia (VT), ventricular
fibrillation (VF), or sudden cardiac death, were observed in 24
patients (19%). Death from any cause or heart transplant was
observed in 39 patients (31%). The amount of interstitial
structured tissue, myofibril volume fraction, and myocytic
fiber diameters determined from left ventricular endomyocardial
biopsy specimens did not differ significantly between patients
with and patients without major arrhythmic events or between
patients with and patients without transplant-free survival
during follow-up. CONCLUSIONS: Quantitative analysis of the
amount of interstitial structured tissue, myofibril volume
fraction, and myocytic fiber diameters in left ventricular
endomyocardial biopsy specimens does not appear to be useful
for predicting arrhythmic events and transplant-free survival
in IDC.
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This item has been published with the following license: In Copyright