Item type:Thesis, Open Access

Prognostische Bedeutung morphometrischer endomyokardialer Biopsieanalysen bei Patienten mit dilatativer Kardiomyopathie

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Date

2004-05-19

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Philipps-Universität Marburg
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Abstract

BACKGROUND: To date, considerable controversy exists on the prognostic significance of morphometric endomyocardial biopsy findings in patients with idiopathic dilated cardiomyopathy (IDC). METHODS: Quantitative analyses of interstitial structured tissue, myofibril volume fraction, and myocytic fiber diameters of left ventricular endomyocardial biopsy specimens were performed in 124 patients with IDC. RESULTS: During 51 +/- 22 months follow-up after left ventricular endomyocardial biopsy, major arrhythmic events, defined as sustained ventricular tachycardia (VT), ventricular fibrillation (VF), or sudden cardiac death, were observed in 24 patients (19%). Death from any cause or heart transplant was observed in 39 patients (31%). The amount of interstitial structured tissue, myofibril volume fraction, and myocytic fiber diameters determined from left ventricular endomyocardial biopsy specimens did not differ significantly between patients with and patients without major arrhythmic events or between patients with and patients without transplant-free survival during follow-up. CONCLUSIONS: Quantitative analysis of the amount of interstitial structured tissue, myofibril volume fraction, and myocytic fiber diameters in left ventricular endomyocardial biopsy specimens does not appear to be useful for predicting arrhythmic events and transplant-free survival in IDC.

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Dates
Created: 2004Issued: 2004-05-19Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2004.0287
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
fibrosissudden cardiac deathbiopsycardiomyopathyDCM , Herzmuskelbiopsie
DFG-subjects
BiopsieSekundenherztod , FibroseKongestive Herzmuskelkrankheit
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2004.0287
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Rudolph, Sylvia: Prognostische Bedeutung morphometrischer endomyokardialer Biopsieanalysen bei Patienten mit dilatativer Kardiomyopathie. : Philipps-Universität Marburg 2004-05-19. DOI: https://doi.org/10.17192/z2004.0287.

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