The bisphosphonate tweezer developed by Schrader et al., which is a selective receptor for recognition of basic amino acids in non-aqueous solvents, was transformed in the scope of this work into a multivalent receptor with a dendrimeric backbone. The affinities of this new generation of dendrimeric receptors in aqueous buffered solution to basic amino acids on the surface of proteins were examined by different spectroskopic methods like PFG-NMR, UV/Vis-Titration and fluorescence measurements.