Sinusendothel-/Virgultumzellen in normalen und pathologisch veränderten menschlichen Lymphknoten. Morphologische Befunde und immunhistochemische Markerprofile
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Philipps-Universität Marburg
Abstract
The lymph node sinus are channel structures of
definite importance in immunology and pathology,
specifically in the filtering of the lymph, the transport and
processing of antigens, the adhesion and migration of immune
cells, and the spread of metastatic cancer cells. Knowledge
of the cell and molecular biology of the sinus-forming cells is
still limited, and the origin and biological nature of these cells
have long been a matter of debate. The dissertation summarizes the relevant
literature and presents experimental results, in
particular concerning molecular markers of intercellular
junctions and cell differentiation. It is shown that both the
monolayer cells lining the sinus walls and the intraluminal
virgultar cell meshwork are indeed different morphotypes of
the same basic endothelial cell character, as demonstrated by
the presence of a distinct spectrum of general and lymphatic
endothelial markers. These sinus endothelial/virgultar cells (SEVCs) form a tight three-dimensional virgultar network along extracellular guidance structures. The network might be considered a local and specific
modification of the general lymphatic vasculature system. Physiological and pathological alterations of SEVC network are presented and discussed.
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This item has been published with the following license: In Copyright