Item type:Thesis, Open Access

Über die Hemmung des Flavivirins Makrocyclische Peptidderivate als Inhibitoren der NS2B-NS3-Protease des Zika-Virus und des West-Nil-Virus

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Date

2023-11-15

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Philipps-Universität Marburg
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Abstract

Flavivirin or the NS2B-NS3 protease is an enzyme essential for the propargation of all Flavivirus species. In this work, the possibilities of inhibiting the Flavivirin of the Zika virus (ZIKV) and the West Nile virus (WNV) with cyclic peptide-derivatives were investigated. For this purpose, more than 100 compounds were synthesised and characterised in enzyme kinetic assays, X-ray crystallography and cell culture experiments. The observed structure activtiy relationships may serve as new starting points of the development of antiviral drugs.

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Dates
Created: 2022Issued: 2023-11-15Updated: 2023-11-15
DOI
https://doi.org/10.17192/z2023.0219
Faculty
Fachbereich Pharmazie
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Drug DesignDengue VirusPeptide SynthesisSerine ProteaseEnzyme Kinetics
DFG-subjects
PeptideWirkstoffdesignEnzymkinetikSerinproteasePeptidsyntheseFlavivirusEnzymeDengue-Virus
DDC-Numbers
615
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2023.0219
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Braun, Niklas Josua (0000-0002-2701-669X): Über die Hemmung des Flavivirins Makrocyclische Peptidderivate als Inhibitoren der NS2B-NS3-Protease des Zika-Virus und des West-Nil-Virus. : Philipps-Universität Marburg 2023-11-15. DOI: https://doi.org/10.17192/z2023.0219.

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This item has been published with the following license: In Copyright