Item type:Thesis, Open Access

Identifizierung potentieller Zielgene des Transkriptionsfaktors Sp3 in vitro und in vivo

Thumbnail Image

Files

dgs.pdf (1.32 MB)

Date

2004-11-25

relationships.isAuthorOf

Publisher

Philipps-Universität Marburg
DOI

item.page.supervisor-of-thesis

Abstract

Sp3 (specificity protein 3) is an ubiquitously expressed transcription factor closely related to Sp1. We have disrupted the mouse Sp3 gene by homologous recombination. Sp3-deficient embryos are growth retarded and invariably die at birth of respiratory failure. The cause for the observed breathing defect remains obscure since only minor morphological alterations were observed in the lung, and surfactant protein expression is indistinguishable from that in wild-type mice. Histopathological examination of the lung revealed that lung tissue of Sp3 null mice is more compact, featuring a smaller mean alveolar space diameter and thicker septa between the alveoli. The intention of my work was to find target genes for transcription factor Sp 3 in vitro an in vivo.

Review

Metadata

Contributors
Supervisor:
Dates
Created: 2004Issued: 2004-11-25Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2004.0612
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Transcription factorTranskriptionsregulationMausKnockout-miceSp3Sp3
DFG-subjects
Knockout Transkriptionsfaktor
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2004.0612
show more
Schmidt, Gabriele: Identifizierung potentieller Zielgene des Transkriptionsfaktors Sp3 in vitro und in vivo. : Philipps-Universität Marburg 2004-11-25. DOI: https://doi.org/10.17192/z2004.0612.

License

item.page.license.under-copyright
This item has been published with the following license: In Copyright