Item type:Thesis, Open Access

Development of new inhibitors for the type II transmembrane serine protease matriptase

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Date

2012-11-16

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Philipps-Universität Marburg
DOI

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Abstract

Several new inhibitors were prepared and tested as potential matriptase inhibitors. The most potent compounds were found among the tertiary amides of arylsulfonylated-3-amidinophenylalanines. The incorporation of suitable bis-substituted biphenylsulfonyl groups in combination with appropriate C-terminal urea structures provided the final strong potent monobasic matriptase inhibitors with acceptable selectivity against related trypsin-like serine proteases. Such compounds are suitable candidates for their further evaluation in cell culture experiments to elucidate the potential role of matriptase in pathophysiological processes

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Dates
Created: 2012Issued: 2012-11-16Updated: 2012-11-16
DOI
https://doi.org/10.17192/z2012.0955
Faculty
Fachbereich Pharmazie
Publisher
Philipps-Universität Marburg
Language
eng
Data types
DoctoralThesis
Keywords
SerinproteaseMatriptaseInhibitorsCancer, InfluenzaMatriptase
DFG-subjects
H9N2 influenza virusCancerMatriptase
DDC-Numbers
500
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2012.0955
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Hammami Maya: Development of new inhibitors for the type II transmembrane serine protease matriptase. : Philipps-Universität Marburg 2012-11-16. DOI: https://doi.org/10.17192/z2012.0955.

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This item has been published with the following license: In Copyright