Item type:Thesis, Open Access

Development and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 protease

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Date

2014-11-26

Authors

Publisher

Philipps-Universität Marburg
DOI

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Abstract

Potent inhibitors of the West Nile virus NS2B-NS3 protease could be useful drugs for the treatment of WNV infections. Therefore, in the present work, new substrate analogue inhibitors against the WNV protease have been developed. In this present work, new decarboxylated arginine memtics inhibitors against the WNV NS2B-NS3 protease were developed. In comparison to the known agmatine derivatives, the P1 trans-4-Guanidinocyclohexylmethylamid containing inhibitors have higher potency and selectivity against the WNV. Moreover, the first crystal structure of the WNV protease in complex with small noncovalently-binding inhibitor was solved.

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Dates
Created: 2014Issued: 2014-11-26
DOI
https://doi.org/10.17192/z2014.0245
Faculty
Fachbereich Pharmazie
Publisher
Philipps-Universität Marburg
Language
eng
Data types
DoctoralThesis
Keywords
Memitic Inhibitor
DFG-subjects
InhibitorHemmstoff
DDC-Numbers
500
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2014.0245
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Hammamy, M. Zouhir (1062570170): Development and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 protease. : Philipps-Universität Marburg 2014-11-26. DOI: https://doi.org/10.17192/z2014.0245.

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