Item type:Thesis, Open Access

Identifikation eines dualen mesokortikolimbischen Dopaminsystems mit selektiven axonalen Projektionen in der adulten Maus (Mus musculus L.)

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Date

2008-02-20

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Publisher

Philipps-Universität Marburg
DOI

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Abstract

The mesocorticolimbic dopamine system is essential for cognitive and emotive brain functions and thus an important target in major brain diseases like schizophrenia, drug addiction and attention-deficit-hyperactivity-disorder. However, the cellular basis for the diversity in behavioral functions and associated dopamine-release pattern within the mesocorticolimbic system has remained unclear. Here I report the identification of a novel type of dopaminergic neuron within the mesocorticolimbic dopamine system with unconventional fast-firing properties and low dopamine transporter (DAT) expression that selectively projects to prefrontal cortex, nucleus accumbens core and to basolateral amygdala. In contrast, well-described conventional slow-firing dopamine midbrain neurons only project to the lateral shell of the nucleus accumbens and the dorsolateral striatum. Among this dual dopamine midbrain system defined in this study by converging anatomical, electrophysiological and molecular properties, mesoprefrontal dopaminergic neurons are unique as only they do not possess functional somatodendritic GIRK2 (G-protein coupled inward rectifying potassium channel 2)-coupled dopamine D2 autoreceptors.

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Dates
Created: 2008Issued: 2008-02-20Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0080
Faculty
Fachbereich Pharmazie
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
MesolimbischTracingMesocorticolimbicMesocorticalMesokortikalMesolimbicRetrograde tracingMesokortikolimbisch
DFG-subjects
DopaminParkinson-KrankheitMittelhirnAufmerksamkeits-Defizit-SyndromSchizophreniePatch-Clamp-Methode
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0080
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Lammel, Stephan (133972259): Identifikation eines dualen mesokortikolimbischen Dopaminsystems mit selektiven axonalen Projektionen in der adulten Maus (Mus musculus L.). : Philipps-Universität Marburg 2008-02-20. DOI: https://doi.org/10.17192/z2008.0080.

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