Die Bedeutung der Surfactantproteine SP-A und SP-D bei der Modulation des Entzündungsprozesses im Rahmen des chronischen Asthma bronchiale
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Philipps-Universität Marburg
Abstract
The function of the surfactant proteins SP-A ans SP-D in modulation of chronic asthma are not completly examined.
The aims of this study were to investigate further the interactions between SP-A and SP-D and type II pneumocytes using a murine model of chronic asthma. After challenging the animals different cytokine receptors - inflammatory and antiinflammatory ones - were detected by PCR and immunohistology.
We found an upregulation of proinflammatory cytokine receptors in abscence of SP-D while these receptors were reduced in absence of SP-A.
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This item has been published with the following license: In Copyright