Item type:Thesis, Open Access

Inhibition der bakteriellen RNA-basierten Ribonuklease P und Untersuchungen zum Reaktionsmechanismus der Protein-basierten Ribonuklease P aus Arabidopsis thaliana

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Date

2016-10-12

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Philipps-Universität Marburg
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Abstract

Bacterial Ribonuclease P (RNase P), which is responsible for the 5’-maturation of precursor tRNAs (pre-tRNA), appears as a very interesting biomolecule. It is a ribozyme that consists of a catalytic RNA and a small auxiliary protein subunit. Moreover, bacterial RNase P differs substantially from RNase P enzymes of the two other domains of life, Archaea and Eukarya, which have recruited multiple protein components during evolution with a concomitant loss of robust RNA-alone activity. In addition, RNase P enzymes that are singular proteins lacking any RNA component have been identified in four of the five eukaryal supergroups. In human, two different RNase P enzymes coexist. The nuclear RNase P contains an RNA component and ten protein subunits, while the mitochondrial RNase P consists of a ternary protein complex devoid of any RNA component. These architectural differences combined with the fact that bacterial RNase P is indispensable for cell survival make the bacterial enzyme a promising target for the development of novel antibiotics. Since no antibiotics are yet known that bind to RNase P as the primary target, inhibitors of bacterial RNase P would open up novel perspectives to combat multiresistant bacterial pathogens.

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Dates
Created: 2016Issued: 2016-10-12Updated: 2017-12-14
DOI
https://doi.org/10.17192/z2016.0677
Faculty
Fachbereich Pharmazie
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Ribonuclease ,Endoribonuclease P ,Arabidopsis ,Heubacillus
DFG-subjects
RibonucleasenEndoribonuklease PHeubacillusSchmalwand
DDC-Numbers
540
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2016.0677
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Walczyk, Dennis: Inhibition der bakteriellen RNA-basierten Ribonuklease P und Untersuchungen zum Reaktionsmechanismus der Protein-basierten Ribonuklease P aus Arabidopsis thaliana. : Philipps-Universität Marburg 2016-10-12. DOI: https://doi.org/10.17192/z2016.0677.

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