Wirkung von Aminfluorid/Zinnfluorid, Triclosan und Acetylsalicylsäure auf PGE2, TXB2 und LTB4 in der Sulkusflüssigkeit bei Patienten mit experimenteller Gingivitis
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Philipps-Universität Marburg
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Abstract
This placebo-controlled double-blind study was
aimed at determining the effects
of mouthrinses containing
amine fluoride/stannous fluoride (AmF/SnF2), triclosan and
acetylsalicylic acid (ASA) on the levels of prostaglandin E2
(PGE2), leukotriene B4 (LTB4 ) and thromboxane B2 (TXB2) in
gingival crevicular
fluid during experimental gingivitis.
44
subjects participated in the study. To establish healthy
gingival conditions,
all subjects underwent a 3 week period of
professional tooth cleaning and oral
hygiene instruction.
Plaque and gingivitis assessments, microbial sampling and
gingival crevicular fluid assessment were performed at
baseline. At the second examination healthy conditions were
recorded. For the next 14 days, the subjects were asked to
abstain from any form of oral hygiene. The 3rd and 4th
examinations were performed at 7 and 14 days from the 2nd
examination. This was followed by random assignment of
mouthrinses containing either AmF/SnF2, triclosan, ASA or
placebo. These mouthrinses were used for 22 days with no
additional oral hygiene measures (rinsing phase). During this
period the 5th and 6th examinations were performed at 25 and 36
days from 2nd examination. Immunological evaluation of the
gingival crevicular fluid (GCF) was done by enzyme immunoessay
(Amersham Pharmaca Biotech UK Limited; Buckinghamshire/UK) with
respect to PGE2, LTB4 and TXB2.
Statistical analysis was based
on the Kruskal-Wallis and the Wilcoxon test.
The findings
revealed no significant change in LTB4 and TXB2 levels during
the experimental gingivitis phase in all four groups, while
PGE2 levels showed
a significant increase between the 2nd and
4th examinations. Combined data from all groups revealed
significant reductions in PGE2 and LTB4 during the rinsing
phase between the 4th and 5th examinations, with levels showing
a subsequent increase between the 5th and 6th examinations,
while TXB2 levels were increased during the rinsing phase.
However, no statistically significant intergroup differences
were observed among the rinsing solutions. The results showed
that PGE2 and LTB4 levels were reduced after 11 days of rinsing
while the TXB2 levels rose during the same period. However,
there was no significant effect among the tested rinsing
solutions in reducing the GCF inflammatory mediators in
experimental gingivitis.This placebo-controlled double-blind study was
aimed at determining the effects
of mouthrinses containing
amine fluoride/stannous fluoride (AmF/SnF2), triclosan and
acetylsalicylic acid (ASA) on the levels of prostaglandin E2
(PGE2), leukotriene B4 (LTB4 ) and thromboxane B2 (TXB2) in
gingival crevicular
fluid during experimental gingivitis.
44
subjects participated in the study. To establish healthy
gingival conditions,
all subjects underwent a 3 week period of
professional tooth cleaning and oral
hygiene instruction.
Plaque and gingivitis assessments, microbial sampling and
gingival crevicular fluid assessment were performed at
baseline. At the second examination healthy conditions were
recorded. For the next 14 days, the subjects were asked to
abstain from any form of oral hygiene. The 3rd and 4th
examinations were performed at 7 and 14 days from the 2nd
examination. This was followed by random assignment of
mouthrinses containing either AmF/SnF2, triclosan, ASA or
placebo. These mouthrinses were used for 22 days with no
additional oral hygiene measures (rinsing phase). During this
period the 5th and 6th examinations were performed at 25 and 36
days from 2nd examination. Immunological evaluation of the
gingival crevicular fluid (GCF) was done by enzyme immunoessay
(Amersham Pharmaca Biotech UK Limited; Buckinghamshire/UK) with
respect to PGE2, LTB4 and TXB2.
Statistical analysis was based
on the Kruskal-Wallis and the Wilcoxon test.
The findings
revealed no significant change in LTB4 and TXB2 levels during
the experimental gingivitis phase in all four groups, while
PGE2 levels showed
a significant increase between the 2nd and
4th examinations. Combined data from all groups revealed
significant reductions in PGE2 and LTB4 during the rinsing
phase between the 4th and 5th examinations, with levels showing
a subsequent increase between the 5th and 6th examinations,
while TXB2 levels were increased during the rinsing phase.
However, no statistically significant intergroup differences
were observed among the rinsing solutions. The results showed
that PGE2 and LTB4 levels were reduced after 11 days of rinsing
while the TXB2 levels rose during the same period. However,
there was no significant effect among the tested rinsing
solutions in reducing the GCF inflammatory mediators in
experimental gingivitis.
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Metadata
Contributors
Supervisor:
Dates
Created: 2003Issued: 2003-12-22Updated: 2011-08-10
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
inflammatory mediatorsamine fluoride/stannous fluorideAminfluorid/Zinnfluorid , Entzündungsmediatoren
DFG-subjects
Leukotriene , ZahnfleischentzündungProstaglandineTriclosan
DDC-Numbers
610
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Kopecz, Sabine (128598395): Wirkung von Aminfluorid/Zinnfluorid, Triclosan und Acetylsalicylsäure auf PGE2, TXB2 und LTB4 in der Sulkusflüssigkeit bei Patienten mit experimenteller Gingivitis. : Philipps-Universität Marburg 2003-12-22. DOI: https://doi.org/10.17192/z2003.0698.
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This item has been published with the following license: In Copyright