Item type:Thesis, Open Access

Novel imantib resistance mechanisms in chronic myloid leukemia

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Date

2007-05-09

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Philipps-Universität Marburg
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Abstract

In my research, I found that the compensatory activation of PI3K/AKT/mTor signaling pathway contributes early imatinib resistance in LAMA cell models. We also found that the auto/paracrine of GM-CSF by imatinib resistant leukemic cells confers to potent imatinib and nilotinib resistance. These findings may serve as a novel strategy to overcome disease resistance to imatinib.

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Dates
Created: 2007Issued: 2007-05-09Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2007.0309
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
eng
Data types
DoctoralThesis
Keywords
Imatinib resistanceConditioned mediumGM-CSFPI3K/Akt pathwayChronic myeloid leukaemia
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2007.0309
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Wang, Ying: Novel imantib resistance mechanisms in chronic myloid leukemia. : Philipps-Universität Marburg 2007-05-09. DOI: https://doi.org/10.17192/z2007.0309.

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This item has been published with the following license: In Copyright