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Chirurgische Rekonstruktionsverfahren nach Tumorresektion bei Patientinnen und Patienten mit primär malignen Knochen- und/oder Weichteiltumoren: Retrospektive Studie zu postoperativen Komplikationen und funktionellem Outcome

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Date

2025-10-21

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Philipps-Universität Marburg
DOI

item.page.supervisor-of-thesis

Abstract

Primary malignant bone and somatic soft tissue tumors are rare diseases. When it comes to overall survival an early diagnosis as well as an individual therapy suitable for each patient is important. This study was initiated to compare various reconstruction procedures regarding postoperative complications, revision rate, reasons for revision as well as functional outcome. A total of 99 patients after tumor resection and reconstruction of a primary malignant bone and somatic soft tissue tumor were retrospectively examined. 101 The reconstruction procedures that were included in this study were MUTARS tumor endoprosthesis (45 patients), biological reconstruction (17), amputation (4), hemipelvectomy (4) and resection without any primary reconstruction procedure (26). On average patients required 2,5 revisions with an unavoidable follow-op operation (type IX according to the in this study newly implemented extended Henderson classification) as the most common reason for a revision. Patients with a MUTARS tumor endoprosthesis had the highest revision rate (3,2), while patients with biological reconstruction and resection without reconstruction only had a revision rate of 2,6. The most common reason for a revision in the MUTARS tumor endoprosthesis patient group was an unavoidable follow-up operation (type IX) at 32%. Patients with biological reconstruction most frequently required revision due to aseptic loosening (23%, type II), while patients with resection without reconstruction mainly required revision due to tumor progression (28%, type V). In addition to postoperative complications and revisions rate, functional outcome after reconstruction also plays an important role in the selection of an appropriate reconstruction procedure. This study showed that 44% of patients with a MUTARS tumor endoprosthesis had a restricted range of motion at the last follow-up, while 35% of patients with biological reconstruction and only 23% of patients after resection without reconstruction had a restricted range of motion. In summary, this study was able to compare five different reconstruction procedures in an inhomogeneous patient population. Within this study it was found that patients with a MUTARS tumor endoprosthesis had the highest revision rate and most restrictions in range of motion. Nevertheless, these data must be viewed critically and other factors, especially the expertise of the surgical team and the tumor center as well as patient preference must be taken into account when selecting the appropriate reconstruction procedure for each individual patient.

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Contributors
Supervisor:
Dates
Created: 2025Issued: 2025-10-21Updated: 2025-10-21
Faculty
Medizin
Language
ger
Data types
DoctoralThesis
Keywords
Bone tumorKnochentumoreEwing-SarcomaChirurgische RekonstruktionsverfahrenHenderson classificationOsteosarcoma
DFG-subjects
Henderson-KlassifikationOsteosarkomEwing-Sarkombiologische RekonstruktionMUTARS-Tumorendoprothese
DDC-Numbers
610
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2025.0170
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Mittelstädt, Sophie Nilam: Chirurgische Rekonstruktionsverfahren nach Tumorresektion bei Patientinnen und Patienten mit primär malignen Knochen- und/oder Weichteiltumoren: Retrospektive Studie zu postoperativen Komplikationen und funktionellem Outcome. : Philipps-Universität Marburg 2025-10-21. DOI: https://doi.org/10.17192/z2025.0170.

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 - CC BY NC ND
Except where otherwised noted, this item's license is described as Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 - CC BY NC ND