Item type:Thesis, Open Access

In vitro VEGF-Sekretion von malignen Schilddrüsenzelllinien:Einfluss von Wachstumsfaktoren und Untersuchung der Postrezeptorsignaltransduktion

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Date

2008-05-23

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Publisher

Philipps-Universität Marburg
DOI

Supervisors

Abstract

After stimulation of three thyroid cancer cell lines with several growth factors VEGF-secretion was analyzed by enzyme immunoassay.TSH was not the most powerfull stimulator of VEGF secretion. TGF-beta and EGF were more potent. In absence of a functional TSHr additional growth factors increase capacity for VEGF sectretion. TSHr signaling was evaluated by analyzing the effect of stimulators and inhibitors on VEGF protein levels under basal and TSH stimulated conditions. The effects of TSH were mediated by PKC rather than PKA.

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Dates
Created: 2008Issued: 2008-05-23Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0360
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
EGFTGF betaThyrotropinPKC
DFG-subjects
Proteinkinase CThyreotropinEpidermaler WachstumsfaktorTransforming Growth Factor beta
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0360
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Geyer, Vera Carina (135554004): In vitro VEGF-Sekretion von malignen Schilddrüsenzelllinien:Einfluss von Wachstumsfaktoren und Untersuchung der Postrezeptorsignaltransduktion. : Philipps-Universität Marburg 2008-05-23. DOI: https://doi.org/10.17192/z2008.0360.

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