Item type:Thesis, Open Access

STAT6-abhängige Stimulation des Osteoklasten-Inhibitors Osteoprotegerin in humanen Endothelzellen durch Interleukin-4 und Interleukin-13

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Date

2009-01-12

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Philipps-Universität Marburg
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Abstract

The (neo)-intimal calcifications of atherosclerotic lesions in the vascular wall are associated with an enhanced risk of cardiovascular events. Osteoprotegrin (OPG) may represent a crucial link between the skeleton and the vascular system in vascular calcification. The aim of this research project was to study how TH2-cytokines IL-4 and IL-13 modulate the expression of OPG in endothelial cells, and whether endothelial OPG can control differentiation and activation of osteoclasts. IL-4 and IL-13 stimulate OPG production in human endothelial cells via STAT6 activation. Endothelial cell-derived OPG specifically inhibits osteoclast activity. Collectively, these data highlight the importance of OPG as an essential common mediator of vascular and bone biology.

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Dates
Created: 2008Issued: 2009-01-12Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0972
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
OsteoclastVaskuläre KalzifizierungInterleukin 4OsteoklastenInterleukin 4Interleukin 13OsteoprotegerinOsteoprotegrinInterleukin 13Vascular calcification
DFG-subjects
Blutgefäß
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0972
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Stein, Nicola C. G.: STAT6-abhängige Stimulation des Osteoklasten-Inhibitors Osteoprotegerin in humanen Endothelzellen durch Interleukin-4 und Interleukin-13. : Philipps-Universität Marburg 2009-01-12. DOI: https://doi.org/10.17192/z2008.0972.

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