Item type:Thesis, Open Access

Synthese und Charakterisierung substratanaloger Inhibitoren der Serinproteasen Matriptase und Kallikrein 7

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Date

2017-08-10

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Publisher

Philipps-Universität Marburg
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Abstract

The serine proteases matriptase and kallikrein 7 are involved in a variety of physiological processes. A disturbed activity of these proteases is responsible for a number of diseases. Therefore, it is of therapeutic interest to be able to regulate the activity of these proteases. For this purpose, a series of substrate-analogue inhibitors for matriptase and kallikrein 7 have been developed and investigated for their inhibitory potency. Potent and selective inhibitors were developed for both proteases.

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Dates
Created: 2017Issued: 2017-08-10Updated: 2018-10-15
DOI
https://doi.org/10.17192/z2017.0531
Faculty
Fachbereich Pharmazie
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Kallikrein7, KLK7, InhibitorsKallikrein7, KLK7, HemmstoffeMatriptaseMatriptase
DFG-subjects
ChemieEnzymkinetikOrganische Chemie
DDC-Numbers
540
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2017.0531
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Maiwald, Alexander: Synthese und Charakterisierung substratanaloger Inhibitoren der Serinproteasen Matriptase und Kallikrein 7. : Philipps-Universität Marburg 2017-08-10. DOI: https://doi.org/10.17192/z2017.0531.

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