Item type:Thesis, Open Access

Wirksamkeit und Verträglichkeit von intraoperativ intravenös verabreichtem Paracetamol und Parecoxib sowie deren Kombination zur Optimierung der postoperativen Analgesie bei mammachirurgischen Eingriffen

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Date

2008-09-09

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Philipps-Universität Marburg
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Abstract

Preemptive Analgesie is still a problem in perioperative medicine. We evaluated the effectiveness and safety of intraoperative intravenous given proparacetamol, parecoxib and a combination of both versus placebo. The aim was to reduce the need of supportive opioid and in consequence to reduce the incidence of typical opioidrelated sideeffects by using this not opioid based analgesia. We found no significant effects in patients undergoing elective mamma surgery.In total, pain levels very low (20-30mm evaluated with a vas-scale). 58% of the patients of the placebo group did not need any further opioid-medication versus 80-85% in the verum-groups but we did not achieve statistical significance. As these results show, patients of this collective had no benefit of preemtive analgesia therefore we can not recommend intravenous paracetamol, parecoxib or a combination of both as a standard treatment.

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Dates
Created: 2008Issued: 2008-09-09Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0594
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Preemptive AnalgesiaParacetamolParacetamolOpioidrelated sideeffectsPostoperative SchmerztherapieParecoxibOpioidbezogene NebenwirkungenParecoxib
DFG-subjects
AnalgesieSchmerztherapie
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0594
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Behrendt, Isabelle: Wirksamkeit und Verträglichkeit von intraoperativ intravenös verabreichtem Paracetamol und Parecoxib sowie deren Kombination zur Optimierung der postoperativen Analgesie bei mammachirurgischen Eingriffen. : Philipps-Universität Marburg 2008-09-09. DOI: https://doi.org/10.17192/z2008.0594.

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