Item type:Thesis, Open Access

Prognostische Bedeutung von B-Typ natriuretischen Peptid-Plasmakonzentrationen bei Patienten mit chronischer Herzinsuffizienz und implantiertem Cardioverter/Defibrillator

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Date

2007-08-01

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Philipps-Universität Marburg
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Abstract

We examined whether B-type natriuretic peptide (BNP) levels predict outcome in heart failure patients with implantable cardioverter defibrillators (ICD) using a combined endpoint of malignant tachyarrhythmias, death or heart transplantation. BNP levels were measured in 123 ICD patients with chronic heart failure (age: 63±12 years, ejection fraction: 29±10%). After a median follow-up of 25 months, the combined endpoint was reached in 28 patients (first tachyarrhythmic event, n=16; death, n=11; heart transplantation, n=1). BNP levels were significantly lower in patients with event-free survival compared to patients reaching the combined endpoint of this study (median: 140 vs. 373 pg/ml; pb0.001). Multivariable Cox regression analysis revealed that BNP levels predict adverse outcome (RR 1.002 per pg/ml increment; 95% CI: 1.001–1.003; pb0.001) and use of beta-blockers was associated with favourable outcome (RR 0.319; 95% CI 0.151–0.670; p=0.004). LV ejection fraction ( p=0.66) did not significantly predict event-free survival in multivariable analysis. BNP plasma levels are useful markers to predict event-free survival in ICD patients with heart failure. Of note, malignant tachyarrhythmias appear responsible for about 50% of fatal outcomes. Our findings suggest that determination of BNP plasma levels is more valuable than determining LV ejection fraction to anticipate event-free survival in this population.

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Dates
Created: 2007Issued: 2007-08-01Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2007.0423
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
PeptideB-TypeNatriureticBrain
DFG-subjects
Brain natriuretic Peptide
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2007.0423
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Bayrakcioglu, Somer: Prognostische Bedeutung von B-Typ natriuretischen Peptid-Plasmakonzentrationen bei Patienten mit chronischer Herzinsuffizienz und implantiertem Cardioverter/Defibrillator. : Philipps-Universität Marburg 2007-08-01. DOI: https://doi.org/10.17192/z2007.0423.

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