Kristallstrukturanalyse und Entwicklung von Computermodellen zur Beschreibung der Selektivität von Enzymen am Beispiel der Carboanhydrase
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Philipps-Universität Marburg
Abstract
To minimize side effects in the drug design process the development of selective inhibitors is very important. Here selective 3D QSAR were generated that allow the extraction of physicochemical properties that are selective for carbonic anhydrase (CA) isozymes.
On the other hand CA isozymes were successfully docked into CA II, compared with the poses in X-ray strcutures and the affinities of these compounds were predicted with the 3D QSAR models.
The cross-reactivity of cyclooxygenase (COX)-2 inhibitors (valdecoxib, celecoxib) with CA was confirmed with affinity data and the X-ray structure of celecoxib in complex with CA II.
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This item has been published with the following license: In Copyright