Item type:Thesis, Open Access

Analyse von Polymorphismen wichtiger Entzündungsmediatoren bei Patienten mit COPD und Bronchialkarzinomen

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Date

2008-05-16

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Philipps-Universität Marburg
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Abstract

COPD and lung cancer are important diseases with high economic impact and increasing incidence worldwide. Caused by missing curative therapeutic options for COPD and at least bad prognosis for lung cancer patients it seems to be point of interest in looking for etiopathogenetic factors of this diseases. In this work polymorphisms of genes of the cytokines TNF-alpha and beta, interleukin 6 and 10 has been investigated in patients with COPD and lung cancer in a case control study. In patients with COPD an in a lung cancer subgroup there was a significant higher frequency of the IL-10 -1082_G polymorphism. The correlation of this polymorphism with the developement of COPD or lung cancer demonstrates a connection between immunological and antiinflamatory processes in the airways with the pathogenesis of these diseases. Also this SNP association could be a factor for risk stratification as well as for serological typing in clinical practice.

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Dates
Created: 2008Issued: 2008-05-16Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2008.0313
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Case control studyInterleukine 10SNPCOPDCytokinesLung cancer
DFG-subjects
SNPFall-Kontroll-StudieCOPDZytokineInterleukin 10Lungenkrebs
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2008.0313
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Plagens, Alexandra (134188128): Analyse von Polymorphismen wichtiger Entzündungsmediatoren bei Patienten mit COPD und Bronchialkarzinomen. : Philipps-Universität Marburg 2008-05-16. DOI: https://doi.org/10.17192/z2008.0313.

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This item has been published with the following license: In Copyright