Item type:Thesis, Open Access

Nachweis von Deletionen der Tumorsuppressorgene TP53 und p16 mittels Fluoreszenz-In-Situ-Hybridisierung bei erwachsenen Patienten mit Philadelphia-Chromosom-positiver akuter lymphatischer Leukämie (ALL)

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Date

2006-11-15

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Publisher

Philipps-Universität Marburg
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Abstract

Deletions of tumor suppressor gene p16 in Philadelphia-chromosome positive adult patients with acute lymphoblastic leukemia can be found by means of fluorescence-in-situ hybridisation in 28% (homozygous) or 8% (hemizygous)respectively (n=25). Hemizygous deletions of tumor suppressor gene TP53 in Philadelphia-chromosome positive adult patients with acute lymphoblastic leukemia can be found by means of fluorescence-in-situ hybridisation in 3%. These hemizygous deletions have often been shown to be due to an isochromosome 17q (n=27).

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Dates
Created: 2006Issued: 2006-11-15Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2006.0522
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
TP53Tumor suppressor geneErwachsenep16AdultsTP53p16Philadelphia-chromosome positiveTumorsuppressorgenPhiladelphia-Chromosom-positiv
DFG-subjects
Akute lymphatische LeukaemieFluoreszenz-in-situ-Hybridisierung
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2006.0522
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Morosan, Thomas (132234475): Nachweis von Deletionen der Tumorsuppressorgene TP53 und p16 mittels Fluoreszenz-In-Situ-Hybridisierung bei erwachsenen Patienten mit Philadelphia-Chromosom-positiver akuter lymphatischer Leukämie (ALL). : Philipps-Universität Marburg 2006-11-15. DOI: https://doi.org/10.17192/z2006.0522.

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