Item type:Thesis, Open Access

Kationenpermeabilität von Erythrozyten bei niedriger Ionenstärke in Abhängigkeit bestimmter Anionen und Inhibitoren unter besonderer Berücksichtigung des Glucosetransporters

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Date

2003-11-13

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Philipps-Universität Marburg
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Abstract

We have reported in human red blood cells in addition to an increase of K+ and Na+ pereability a decrease in glucose efflux in low-chloride media. Pig red cells without glucose transporter do not show such cation efflux. A substantial portion of cation efflux in human red blood cells is inhibited by DIDS in low-anion concentration. We added DIDS one minute after Cl-/OH--exchange and measured in K+-efflux a Ki of 98 nM DIDS. It is without effect in regular glucose efflux, but reverses partly inhibition of glucose efflux in low-chloride media. Phenylglyoxal inhibits both cation efflux in low-chloride media. We found at 0.8 mM chloride by adding SDS after Cl-/OH--exchange an activation of cation efflux with an EC50 of 17

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Dates
Created: 2003Issued: 2003-11-13Updated: 2011-08-10
DOI
https://doi.org/10.17192/z2003.0693
Faculty
Medizin
Publisher
Philipps-Universität Marburg
Language
ger
Data types
DoctoralThesis
Keywords
Effluxerythrocytepermeabilityeffluxcation
DFG-subjects
ErythrozytenmembranErythrozytKationPermeabilität
DDC-Numbers
610
License
https://rightsstatements.org/vocab/InC-NC/1.0/
URI
https://open.uni-marburg.de/handle/10.17192/z2003.0693
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Bruness, Florian (128509937): Kationenpermeabilität von Erythrozyten bei niedriger Ionenstärke in Abhängigkeit bestimmter Anionen und Inhibitoren unter besonderer Berücksichtigung des Glucosetransporters. : Philipps-Universität Marburg 2003-11-13. DOI: https://doi.org/10.17192/z2003.0693.

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