The development of nanostructured lipid carriers for lipidic antioxidant: a study on CoQ10
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Philipps-Universität Marburg
Abstract
Under excessive UV radiation, the equilibrium condition between the free radicals and the antioxidants could not be achieved due to the accumulation of reactive oxygen species (ROS). The impendent state called oxidative stress contributes to skin aging and photodamage, including solar erythema, resulting in skin decay. Administration of exogenous antioxidants can support endogenous antioxidants, for example, by topically applying a cream containing CoQ10 to the skin. CoQ10 is one of the antioxidants commonly used in anti-aging products; however, the skin's function inhibits the dermal penetration of CoQ10 as a barrier.
One approach to improving topically applied substances' performance is by using nanolipids. Utilizing the high-pressure homogenization (HPH) method on a lipid mixture comprising of solid:liquid lipid (20:80%), a nanolipid so-called ultra-small nanostructured lipid carriers (usNLCs) were successful in promoting the dermal delivery of the CoQ10. The size of these particles was around 80 nm; hence the term "ultra-small" was used. In this study, the "ultra-small" was dropped to simplify.
The current work was developed to explore the potency of CoQ10 nanolipids as a topical antioxidant. The first part of this thesis (chapter 3.1) was to develop the nanolipids using a broad range of solid and liquid lipids ratios. The resulting nanolipids were analyzed to determine the effect of different matrices on physical properties, skin bioproperties, and skin penetration. Next, to visualize the impact of the lipid matrices in delivering a substance through the skin layer, fluorescing dil nanolipids were produced, and observations of dil penetration were carried out under a microscope. The second part (chapter 3.2) was to prove the anti-inflammatory effect of CoQ10 nanolipids in vivo in rats irradiated with UVB.
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Except where otherwise noted, this item's license is described as Creative Commons Attribution-NonCommercial 4.0 - CC BY NC