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The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

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PIIS0085253824003892.pdf (6.18 MB)

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2024-09-23

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Philipps-Universität Marburg
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Abstract

This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively
Uncontrolled complement activation can cause or contribute to glomerular injury in multiple kidney diseases. Although complement activation plays a causal role in atypical hemolytic uremic syndrome and C3 glomerulopathy, over the past decade, a rapidly accumulating body of evidence has shown a role for complement activation in multiple other kidney diseases, including diabetic nephropathy and several glomerulonephritides. The number of available complement inhibitor therapies has also increased during the same period. In 2022, Kidney Diseases: Improving Global Outcomes (KDIGO) convened a Controversies Conference, “The Role of Complement in Kidney Disease,” to address the expanding role of complement dysregulation in the pathophysiology, diagnosis, and management of various glomerular diseases, diabetic nephropathy, and other forms of hemolytic uremic syndrome. Conference participants reviewed the evidence for complement playing a primary causal or secondary role in progression for several disease states and considered how evidence of complement involvement might inform management. Participating patients with various complement-mediated diseases and caregivers described concerns related to life planning, implications surrounding genetic testing, and the need for inclusive implementation of effective novel therapies into clinical practice. The value of biomarkers in monitoring disease course and the role of the glomerular microenvironment in complement response were examined, and key gaps in knowledge and research priorities were identified.

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Dates
Created: 2024Issued: 2024-09-23Updated: 2024-09-23
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Is part of: es/2024/0401
Faculty
Medizin
Language
eng
Data types
Article
Keywords
complement inhibitor complement-mediated injury glomerular injuryKomplement-Inhibitor Komplement-vermittelte Verletzung glomeruläre Schädigung
DDC-Numbers
570
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
URI
https://open.uni-marburg.de/handle/10.17192/es.2024.0930
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Marina Vivarelli; Jonathan Barratt; Laurence H. Beck, Jr; Fadi Fakhouri; Daniel P. Gale; Elena Goicoechea de Jorge; Marta Mosca; Marina Noris; Matthew C. Pickering; Katalin Susztak; Joshua M. Thurman; Michael Cheung; Jennifer M. King; Michel Jadoul; Wolfgang C. Winkelmayer; Richard J.H. Smith: The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. In: , Jg. (2024-09-23), . DOI: https://doi.org/10.1016/j.kint.2024.05.015.

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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 - CC BY NC ND
Except where otherwised noted, this item's license is described as Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 - CC BY NC ND