Curcumin Microemulsions: Influence of Compositions on the Dermal Penetration Efficacy
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MDPI
Abstract
This study provided a comparison of the influence of
each component of the microemulsion formulation and investigated the impact of varying
concentrations of the microemulsion components on curcumin’s ability to penetrate the
skin using an ex vivo porcine ear model. Methods: Curcumin microemulsions with
different compositions were prepared and analyzed for their physicochemical properties.
The dermal penetration efficacy of curcumin was evaluated from the different formulations
and compared with non-microemulsion formulations. Results: Findings proved that
microemulsion formulations improve the dermal penetration efficacy for curcumin when
compared with non-microemulsion formulations. The composition of the microemulsion
affects the penetration efficacy of curcumin and increases with decreasing oil content and
increasing surfactant and water content. The best penetration for curcumin is achieved
with a microemulsion that contained 7.7 g of medium-chain triglycerides as the oil phase,
6.92 g of Tween® 80 and 62.28 g of ethanol as the surfactant mixture, and 23.1 g water.
Conclusions: The present study provides a foundational basis for further development
of different microemulsion formulations for enhancing the dermal penetration of poorly
water-soluble active compounds.
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Except where otherwised noted, this item's license is described as Attribution 4.0 International