Individualdifferencesindopamine-relatedtraitsinfluencemoodeffectsofdopamineD2-antagonistandantidepressanttreatmentexpectations
Loading...
Files
Date
Authors
Publisher
Oxford University Press
Abstract
Background:
Hightraitanhedoniaandlowtraitextraversionhavebothbeenpreviouslyrelatedtonotonlylowstatepositiveaffectbutalsodepressivedisorders,disruptedrewardprocessing,andalteredmesolimbicdopaminergicsignaling.Researchonplaceboresponsessuggeststhattreatmentexpectationsmayalterdopaminesignaling,elevatepositiveaffect,andreducedepressivesymptomsinanhedonicindividuals.However,itremainsunclearwhethersuchantidepressantplaceboresponsesdependonputativelowbaselinedopaminergicfunctioninginhighanhedoniaandlowextraversion.Thepresentstudyinvestigateshowinterindividualdifferencesinthesetraitsinfluencepositiveaffectiveresponsesundermanipulationofdopamineandtreatmentexpectations.
Methods:
Inarandomized,double-blind2×2design(N=297),weadministeredeitherplaceboorthedopamineD2receptorantagonistsulpiride(400mg),andmanipulatedtreatmentexpectationsbytellingparticipantsthattheyreceivedeitheramood-elevatingdrugoraninactivesubstance.Moreover,weassessedtraitanhedoniaandextraversion,andhadparticipantsratetheirstatepositiveaffectat6differenttimepointsbeforeandaftertreatment.
Results:
Traitanhedoniaandextraversion,aswellasabroadtraitpositiveaffectivityfactor,predictedstatepositiveaffectacrosstimepoints.Importantly,theeffectsofsulpirideandantidepressanttreatmentexpectationsonpositiveaffectweremoderatedbydopaminergictraitssuchthatsulpirideincreasedstatepositiveaffectinhighanhedoniabutdecreaseditinlowanhedonia.Similarly,antidepressanttreatmentexpectationsraisedpositiveaffectinlowextraversionbutreduceditinhighextraversion.
Conclusions:
Thisstudydemonstratesthatdopamine-relatedindividualdifferencesmoderatetheeffectsofbothsulpirideandaplacebointerventiononpositiveaffectivestate.
Metadata
License
Except where otherwise noted, this item's license is described as Attribution 4.0 International