Regulatory Roles of miR-155-5p, miR-21-5p, miR-93-5p, and miR-140-5p in Breast Cancer Progression
Loading...
Date
Publisher
MDPI
Abstract
Breast cancer (BC) remains the leading cause of cancer-related morbidity
and mortality worldwide, necessitating innovative approaches to improve diagnosis,
prognosis, and treatment. This case-control study, aimed to evaluate the expression
profiles of specific microRNAs (miRNAs)—miR-155-5p, miR-21-5p, miR-93-5p, and
miR-140-5p—in 50 female BC patients treated with paclitaxel (PTX) compared to 50 healthy
controls. miRNA expression was analyzed using qPCR. The study revealed significant
up regulation of these miRNAs in BC patients, with miR-155-5p and miR-21-5p demonstrating
the highest diagnostic accuracy (AUC = 0.890 and 0.863, respectively). These
miRNAs are implicated in key oncogenic processes, including tumor growth, angiogenesis,
metastasis, and chemoresistance, highlighting their potential as non-invasive biomarkers
for BC diagnosis and prognosis. Additionally, the study identified significant differences
in demographic and biochemical parameters between BC patients and controls, such as
lower hemoglobin and RBC counts in patients, indicative of cancer-related anemia, and
elevated AST levels. The findings underscore the importance of miRNAs in BC biology and
their potential to guide personalized therapeutic strategies. Validation in larger cohorts is
recommending and exploring miRNA-based interventions to improve patient outcomes
and overcome chemoresistance in BC.
Metadata
License
Except where otherwised noted, this item's license is described as Attribution 4.0 International