first_page settings Order Article Reprints Open AccessReview Challenges, Unmet Needs, and Future Directions for Nanocrystals in Dermal Drug Delivery
Loading...
Date
Authors
Publisher
MDPI
Abstract
Nanocrystals, defined as crystalline particles with dimensions in the nanometer range
(<1000 nm), exhibit unique properties that enhance the efficacy of poorly soluble active
compounds. This review explores the fundamental aspects of nanocrystals, including
their characteristics and various preparation methods, while addressing critical factors that
influence their stability and incorporation into final products. A key focus of the review is
the advantages offered by nanocrystals in dermal applications. It also highlights their ability
to enhance passive diffusion into the skin and facilitate penetration via particle-assisted
dermal penetration. Additionally, the review discusses their capacity to penetrate into hair
follicles, enabling targeted drug delivery, and their synergistic potential when combined
with microneedles, which further enhance the dermal absorption of active compounds. The
review also addresses several commercial products that successfully employ nanocrystal
technology, showcasing its practical applications. Summary: Nanocrystals with their special
properties are an emerging trend for dermal applications, particularly the development
of plantCrystals—natural nanocrystals sourced from plant materials—which represent a
promising path for future research and formulation strategies. These advancements could
lead to more sustainable and effective dermal products.
Metadata
License
Except where otherwise noted, this item's license is described as Attribution 4.0 International